Extrapyramidal symptoms (EPS) rapidly subsided in response to an intramuscular injection of biperiden. Blood biochemical tests revealed an elevated serum prolactin level of 44 ng/mL. After. Extrapyramidal symptoms (EPS), also known as extrapyramidal side effects (EPSE), are drug-induced movement disorders that include acute and tardive symptoms. ORIGINAL ARTICLES Metoclopramide and Extrapyramidal Symptoms: A Case Report Daniel D. Moos, CRNA, MS, Debra J. Hansen, PharmD, RP Metoclopramideis auseful medicationintheanesthesia provider’s Metoclopramide is a useful medication in the anesthesia provider's armamentarium. Its primary indication in the preoperative phase is to reduce gastric contents and increase lower esophageal sphincter tone for pharmacologic pulmonary aspiration prophylaxis. Metoclopramide is a useful medication in the anesthesia provider's armamentarium. Its primary indication in the preoperative phase is to reduce gastric contents and increase lower esophageal sphincter tone for pharmacologic pulmonary aspiration prophylaxis. Metoclopramide can precipitate REGLAN helps treat symptoms such as nausea, vomiting, heartburn, feeling full long after a meal, and loss of appetite. Not all these symptoms get better at the same time. Not all these symptoms get better at the same time. Extrapyramidal side effects after metoclopramide administration in a post-anesthesia care unit -A case report- Youn Yi Jo , Yong Beom Kim , Mi Ran Yang , and Young Jin Chang Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science Gil Medical Center, Incheon, Korea. However, if severe symptoms are present, therapy should begin with Reglan Injection (IM or IV). Doses of 10 mg may be administered slowly by the intravenous route over a 1- to 2-minute period. Doses of 10 mg may be administered slowly by the intravenous route over a 1- to 2-minute period. Reglan and Abnormal Involuntary Movements (Extrapyramidal Symptoms) in Children Reglan has been linked to abnormal involuntary movements, or extrapyramidal symptoms, in children. In January 2015, Health Canada issued a warning letter to health care professionals in collaboration with Sandoz Canada Inc., Apotex Inc., Omega Laboratories, and the Pendopharm Division of Pharmascience Inc. warning. The extrapyramidal system can be affected in a number of ways, which are revealed in a range of extrapyramidal symptoms (EPS), also known as extrapyramidal side-effects (EPSE), such as akinesia.